4-6 February 2019
Centara Grand at Central Ladprao
Asia/Bangkok timezone
Deadline for full paper revision: 21 May 2019.

Evaluation of Radiation-treated Turmeric Dressing for the Wound Healing Potential in Rat Model

5 Feb 2019, 14:40
1h 10m
Centara Grand at Central Ladprao

Centara Grand at Central Ladprao

Chatuchak, Bangkok 10900, Thailand
Poster Medical Poster 2

Speaker

Dr Pimpon Uttayarat (Research and Development Unit, Thailand Institute of Nuclear Technology (Public Organization))

Description

Curcumin, a naturally derived substance from turmeric, is a well-known topical wound healing agent, which exhibits various properties such as anti-inflammatory, anti-oxidant, and antimicrobial. In this work, we tested the efficacy of crude curcumin prepared from turmeric powder for its wound healing effect in rats. The as-received, commercial Thai turmeric powder was first dissolved in glycerol to make an ointment before sterilization by gamma rays at 25 kGy. HPLC data showed that the curcumin content in irradiated turmeric ointment decreased by about 2.5 folds compared to non-irradiated sample. Full-thickness wounds of size 6 mm in diameter were made surgically on the dorsal side of Sprague Dawley rats, and irradiated turmeric ointment was administered topically. In terms of epithelial healing, wound closure in turmeric-treated rats was observed to be similar to the non-treated group on days 14 and 21 post-wounding. However, histological examination revealed that turmeric better promoted dermal healing as characterized by increasing collagen formation, decreasing granulation tissue, and modulating inflammatory responses especially macrophage and giant cell depositions. Based on these initial results, the use of crude curcumin in irradiated turmeric solution has demonstrated its potential to promote wound healing at the cellular level in animal model.

Primary authors

Dr Pimpon Uttayarat (Research and Development Unit, Thailand Institute of Nuclear Technology (Public Organization)) Ms Rattanakorn Chiangnoon (Research and Development Unit, Thailand Institute of Nuclear Technology (Public Organization)) Ms Wachiraporn Pewlong (Research and Development Unit, Thailand Institute of Nuclear Technology (Public Organization)) Mr Surasak Sajjabutt (Research and Development Unit, Thailand Institute of Nuclear Technology (Public Organization)) Ms Wannee Angkhasirisap (National Laboratory Animal Center, Mahidol University) Dr Sumate Ampawong (Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University)

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